Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database.
Identifieur interne : 001895 ( Main/Exploration ); précédent : 001894; suivant : 001896Prognosis of patients with peritoneal metastatic colorectal cancer given systemic therapy: an analysis of individual patient data from prospective randomised trials from the Analysis and Research in Cancers of the Digestive System (ARCAD) database.
Auteurs : Jan Franko [États-Unis] ; Qian Shi [États-Unis] ; Jeffrey P. Meyers [États-Unis] ; Timothy S. Maughan [Royaume-Uni] ; Richard A. Adams [Royaume-Uni] ; Matthew T. Seymour [Royaume-Uni] ; Leonard Saltz [États-Unis] ; Cornelis J A. Punt [Pays-Bas] ; Miriam Koopman [Pays-Bas] ; Christophe Tournigand [France] ; Niall C. Tebbutt [Australie] ; Eduardo Diaz-Rubio [Espagne] ; John Souglakos [Grèce] ; Alfredo Falcone [Italie] ; Benoist Chibaudel [France] ; Volker Heinemann [Allemagne] ; Joseph Moen [États-Unis] ; Aimery De Gramont [France] ; Daniel J. Sargent [États-Unis] ; Axel Grothey [États-Unis]Source :
- The Lancet. Oncology [ 1474-5488 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- mortalité : Tumeurs colorectales.
- secondaire : Tumeurs du péritoine.
- traitement médicamenteux : Tumeurs colorectales.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Modèles de hasards proportionnels, Mâle, Pronostic, Sujet âgé, Sujet âgé de 80 ans ou plus, Études prospectives.
English descriptors
- KwdEn :
- MESH :
- drug therapy : Colorectal Neoplasms.
- mortality : Colorectal Neoplasms.
- secondary : Peritoneal Neoplasms.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Prognosis, Proportional Hazards Models, Prospective Studies.
Abstract
Patients with peritoneal metastatic colorectal cancer have reduced overall survival compared with patients with metastatic colorectal cancer without peritoneal involvement. Here we further investigated the effect of the number and location of metastases in patients receiving first-line systemic chemotherapy.
DOI: 10.1016/S1470-2045(16)30500-9
PubMed: 27743922
Affiliations:
- Allemagne, Australie, Espagne, France, Grèce, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Bavière, Communauté de Madrid, District de Haute-Bavière, Hollande-Septentrionale, Iowa, Minnesota, Nouvelle-Galles du Sud, Oxfordshire, Toscane, Utrecht (province), État de New York, Île-de-France
- Amsterdam, Créteil, Iowa City, Madrid, Munich, Oxford, Pise, Sydney, Utrecht
- Université Louis-et-Maximilien de Munich, Université d'Amsterdam, Université de Pise, Université de Sydney, Université de l'Iowa
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Le document en format XML
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Seymour</name><affiliation wicri:level="1"><nlm:affiliation>Gastrointestinal Cancer Research Unit, Cookridge Hospital, Leeds, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Gastrointestinal Cancer Research Unit, Cookridge Hospital, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Saltz, Leonard" sort="Saltz, Leonard" uniqKey="Saltz L" first="Leonard" last="Saltz">Leonard Saltz</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Punt, Cornelis J A" sort="Punt, Cornelis J A" uniqKey="Punt C" first="Cornelis J A" last="Punt">Cornelis J A. Punt</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Koopman, Miriam" sort="Koopman, Miriam" uniqKey="Koopman M" first="Miriam" last="Koopman">Miriam Koopman</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Tournigand, Christophe" sort="Tournigand, Christophe" uniqKey="Tournigand C" first="Christophe" last="Tournigand">Christophe Tournigand</name><affiliation wicri:level="3"><nlm:affiliation>Hopital Henri Mondor, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Henri Mondor, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Tebbutt, Niall C" sort="Tebbutt, Niall C" uniqKey="Tebbutt N" first="Niall C" last="Tebbutt">Niall C. Tebbutt</name><affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, the University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, the University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Diaz Rubio, Eduardo" sort="Diaz Rubio, Eduardo" uniqKey="Diaz Rubio E" first="Eduardo" last="Diaz-Rubio">Eduardo Diaz-Rubio</name><affiliation wicri:level="3"><nlm:affiliation>Department Oncology; Hospital Cliínico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department Oncology; Hospital Cliínico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Souglakos, John" sort="Souglakos, John" uniqKey="Souglakos J" first="John" last="Souglakos">John Souglakos</name><affiliation wicri:level="1"><nlm:affiliation>University of Crete, School of Medicine, Heraklion, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Crete, School of Medicine, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Falcone, Alfredo" sort="Falcone, Alfredo" uniqKey="Falcone A" first="Alfredo" last="Falcone">Alfredo Falcone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Chibaudel, Benoist" sort="Chibaudel, Benoist" uniqKey="Chibaudel B" first="Benoist" last="Chibaudel">Benoist Chibaudel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Franco-British Institute, Levallois-Perret, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Franco-British Institute, Levallois-Perret</wicri:regionArea><wicri:noRegion>Levallois-Perret</wicri:noRegion><wicri:noRegion>Levallois-Perret</wicri:noRegion></affiliation></author><author><name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name><affiliation wicri:level="4"><nlm:affiliation>University of Munich, Department of Medical Oncology and Comprehensive Cancer Center, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Munich, Department of Medical Oncology and Comprehensive Cancer Center, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Moen, Joseph" sort="Moen, Joseph" uniqKey="Moen J" first="Joseph" last="Moen">Joseph Moen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biostatistics, University of Iowa, Iowa City, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="De Gramont, Aimery" sort="De Gramont, Aimery" uniqKey="De Gramont A" first="Aimery" last="De Gramont">Aimery De Gramont</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Franco-British Institute, Levallois-Perret, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Franco-British Institute, Levallois-Perret</wicri:regionArea><wicri:noRegion>Levallois-Perret</wicri:noRegion><wicri:noRegion>Levallois-Perret</wicri:noRegion></affiliation></author><author><name sortKey="Sargent, Daniel J" sort="Sargent, Daniel J" uniqKey="Sargent D" first="Daniel J" last="Sargent">Daniel J. 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Electronic address: jan.franko@gmail.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Surgical Oncology, Mercy Medical Center, Des Moines, IA</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Shi, Qian" sort="Shi, Qian" uniqKey="Shi Q" first="Qian" last="Shi">Qian Shi</name><affiliation wicri:level="2"><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Meyers, Jeffrey P" sort="Meyers, Jeffrey P" uniqKey="Meyers J" first="Jeffrey P" last="Meyers">Jeffrey P. Meyers</name><affiliation wicri:level="2"><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Maughan, Timothy S" sort="Maughan, Timothy S" uniqKey="Maughan T" first="Timothy S" last="Maughan">Timothy S. Maughan</name><affiliation wicri:level="3"><nlm:affiliation>CRUK/MRC Oxford Institute for Radiation Oncology, Oxford, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRUK/MRC Oxford Institute for Radiation Oncology, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Adams, Richard A" sort="Adams, Richard A" uniqKey="Adams R" first="Richard A" last="Adams">Richard A. Adams</name><affiliation wicri:level="1"><nlm:affiliation>Cardiff University, Cardiff, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cardiff University, Cardiff</wicri:regionArea><wicri:noRegion>Cardiff</wicri:noRegion></affiliation></author><author><name sortKey="Seymour, Matthew T" sort="Seymour, Matthew T" uniqKey="Seymour M" first="Matthew T" last="Seymour">Matthew T. Seymour</name><affiliation wicri:level="1"><nlm:affiliation>Gastrointestinal Cancer Research Unit, Cookridge Hospital, Leeds, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Gastrointestinal Cancer Research Unit, Cookridge Hospital, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Saltz, Leonard" sort="Saltz, Leonard" uniqKey="Saltz L" first="Leonard" last="Saltz">Leonard Saltz</name><affiliation wicri:level="2"><nlm:affiliation>Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Punt, Cornelis J A" sort="Punt, Cornelis J A" uniqKey="Punt C" first="Cornelis J A" last="Punt">Cornelis J A. Punt</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Oncology, Academic Medical Center, University of Amsterdam, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region><settlement type="city">Amsterdam</settlement></placeName><orgName type="university">Université d'Amsterdam</orgName></affiliation></author><author><name sortKey="Koopman, Miriam" sort="Koopman, Miriam" uniqKey="Koopman M" first="Miriam" last="Koopman">Miriam Koopman</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Tournigand, Christophe" sort="Tournigand, Christophe" uniqKey="Tournigand C" first="Christophe" last="Tournigand">Christophe Tournigand</name><affiliation wicri:level="3"><nlm:affiliation>Hopital Henri Mondor, Creteil, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hopital Henri Mondor, Creteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Tebbutt, Niall C" sort="Tebbutt, Niall C" uniqKey="Tebbutt N" first="Niall C" last="Tebbutt">Niall C. Tebbutt</name><affiliation wicri:level="4"><nlm:affiliation>Sydney Medical School, the University of Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, the University of Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Diaz Rubio, Eduardo" sort="Diaz Rubio, Eduardo" uniqKey="Diaz Rubio E" first="Eduardo" last="Diaz-Rubio">Eduardo Diaz-Rubio</name><affiliation wicri:level="3"><nlm:affiliation>Department Oncology; Hospital Cliínico San Carlos, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department Oncology; Hospital Cliínico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Souglakos, John" sort="Souglakos, John" uniqKey="Souglakos J" first="John" last="Souglakos">John Souglakos</name><affiliation wicri:level="1"><nlm:affiliation>University of Crete, School of Medicine, Heraklion, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>University of Crete, School of Medicine, Heraklion</wicri:regionArea><wicri:noRegion>Heraklion</wicri:noRegion></affiliation></author><author><name sortKey="Falcone, Alfredo" sort="Falcone, Alfredo" uniqKey="Falcone A" first="Alfredo" last="Falcone">Alfredo Falcone</name><affiliation wicri:level="4"><nlm:affiliation>Department of Oncology, University of Pisa, Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oncology, University of Pisa, Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region nuts="2">Toscane</region><settlement type="city">Pise</settlement></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Chibaudel, Benoist" sort="Chibaudel, Benoist" uniqKey="Chibaudel B" first="Benoist" last="Chibaudel">Benoist Chibaudel</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Franco-British Institute, Levallois-Perret, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Franco-British Institute, Levallois-Perret</wicri:regionArea><wicri:noRegion>Levallois-Perret</wicri:noRegion><wicri:noRegion>Levallois-Perret</wicri:noRegion></affiliation></author><author><name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name><affiliation wicri:level="4"><nlm:affiliation>University of Munich, Department of Medical Oncology and Comprehensive Cancer Center, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University of Munich, Department of Medical Oncology and Comprehensive Cancer Center, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Moen, Joseph" sort="Moen, Joseph" uniqKey="Moen J" first="Joseph" last="Moen">Joseph Moen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biostatistics, University of Iowa, Iowa City, IA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, University of Iowa, Iowa City, IA</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="De Gramont, Aimery" sort="De Gramont, Aimery" uniqKey="De Gramont A" first="Aimery" last="De Gramont">Aimery De Gramont</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Franco-British Institute, Levallois-Perret, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Medical Oncology, Franco-British Institute, Levallois-Perret</wicri:regionArea><wicri:noRegion>Levallois-Perret</wicri:noRegion><wicri:noRegion>Levallois-Perret</wicri:noRegion></affiliation></author><author><name sortKey="Sargent, Daniel J" sort="Sargent, Daniel J" uniqKey="Sargent D" first="Daniel J" last="Sargent">Daniel J. Sargent</name><affiliation wicri:level="2"><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Grothey, Axel" sort="Grothey, Axel" uniqKey="Grothey A" first="Axel" last="Grothey">Axel Grothey</name><affiliation wicri:level="2"><nlm:affiliation>Department of Oncology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author></analytic><series><title level="j">The Lancet. Oncology</title><idno type="eISSN">1474-5488</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Colorectal Neoplasms (drug therapy)</term><term>Colorectal Neoplasms (mortality)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Peritoneal Neoplasms (secondary)</term><term>Prognosis</term><term>Proportional Hazards Models</term><term>Prospective Studies</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs colorectales (mortalité)</term><term>Tumeurs colorectales (traitement médicamenteux)</term><term>Tumeurs du péritoine (secondaire)</term><term>Études prospectives</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du péritoine</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Peritoneal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs colorectales</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prognosis</term><term>Proportional Hazards Models</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Pronostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Patients with peritoneal metastatic colorectal cancer have reduced overall survival compared with patients with metastatic colorectal cancer without peritoneal involvement. Here we further investigated the effect of the number and location of metastases in patients receiving first-line systemic chemotherapy.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Grèce</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Bavière</li><li>Communauté de Madrid</li><li>District de Haute-Bavière</li><li>Hollande-Septentrionale</li><li>Iowa</li><li>Minnesota</li><li>Nouvelle-Galles du Sud</li><li>Oxfordshire</li><li>Toscane</li><li>Utrecht (province)</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Créteil</li><li>Iowa City</li><li>Madrid</li><li>Munich</li><li>Oxford</li><li>Pise</li><li>Sydney</li><li>Utrecht</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Amsterdam</li><li>Université de Pise</li><li>Université de Sydney</li><li>Université de l'Iowa</li></orgName></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Franko, Jan" sort="Franko, Jan" uniqKey="Franko J" first="Jan" last="Franko">Jan Franko</name></region><name sortKey="Grothey, Axel" sort="Grothey, Axel" uniqKey="Grothey A" first="Axel" last="Grothey">Axel Grothey</name><name sortKey="Meyers, Jeffrey P" sort="Meyers, Jeffrey P" uniqKey="Meyers J" first="Jeffrey P" last="Meyers">Jeffrey P. Meyers</name><name sortKey="Moen, Joseph" sort="Moen, Joseph" uniqKey="Moen J" first="Joseph" last="Moen">Joseph Moen</name><name sortKey="Saltz, Leonard" sort="Saltz, Leonard" uniqKey="Saltz L" first="Leonard" last="Saltz">Leonard Saltz</name><name sortKey="Sargent, Daniel J" sort="Sargent, Daniel J" uniqKey="Sargent D" first="Daniel J" last="Sargent">Daniel J. Sargent</name><name sortKey="Shi, Qian" sort="Shi, Qian" uniqKey="Shi Q" first="Qian" last="Shi">Qian Shi</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Maughan, Timothy S" sort="Maughan, Timothy S" uniqKey="Maughan T" first="Timothy S" last="Maughan">Timothy S. Maughan</name></region><name sortKey="Adams, Richard A" sort="Adams, Richard A" uniqKey="Adams R" first="Richard A" last="Adams">Richard A. Adams</name><name sortKey="Seymour, Matthew T" sort="Seymour, Matthew T" uniqKey="Seymour M" first="Matthew T" last="Seymour">Matthew T. Seymour</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Punt, Cornelis J A" sort="Punt, Cornelis J A" uniqKey="Punt C" first="Cornelis J A" last="Punt">Cornelis J A. Punt</name></region><name sortKey="Koopman, Miriam" sort="Koopman, Miriam" uniqKey="Koopman M" first="Miriam" last="Koopman">Miriam Koopman</name></country><country name="France"><region name="Île-de-France"><name sortKey="Tournigand, Christophe" sort="Tournigand, Christophe" uniqKey="Tournigand C" first="Christophe" last="Tournigand">Christophe Tournigand</name></region><name sortKey="Chibaudel, Benoist" sort="Chibaudel, Benoist" uniqKey="Chibaudel B" first="Benoist" last="Chibaudel">Benoist Chibaudel</name><name sortKey="De Gramont, Aimery" sort="De Gramont, Aimery" uniqKey="De Gramont A" first="Aimery" last="De Gramont">Aimery De Gramont</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Tebbutt, Niall C" sort="Tebbutt, Niall C" uniqKey="Tebbutt N" first="Niall C" last="Tebbutt">Niall C. Tebbutt</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Diaz Rubio, Eduardo" sort="Diaz Rubio, Eduardo" uniqKey="Diaz Rubio E" first="Eduardo" last="Diaz-Rubio">Eduardo Diaz-Rubio</name></region></country><country name="Grèce"><noRegion><name sortKey="Souglakos, John" sort="Souglakos, John" uniqKey="Souglakos J" first="John" last="Souglakos">John Souglakos</name></noRegion></country><country name="Italie"><region name="Toscane"><name sortKey="Falcone, Alfredo" sort="Falcone, Alfredo" uniqKey="Falcone A" first="Alfredo" last="Falcone">Alfredo Falcone</name></region></country><country name="Allemagne"><region name="Bavière"><name sortKey="Heinemann, Volker" sort="Heinemann, Volker" uniqKey="Heinemann V" first="Volker" last="Heinemann">Volker Heinemann</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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